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Previous reports have suggested that both repetitive head trauma and a single injury can be associated with the presence of diffuse BA4 amyloid protein plaques in long-term survivors.We have studied sixteen patients (aged 10-63 years)who sustained head injury and survived for only 6-18 days.Immunostaining with an antibody to BA4 amyloid showed extensive deposits of the protein in the cortex in six of the sixteen patients(38%). Thus,severe head injury can trigger BA4 deposition in the brain within days. |
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